In imaging of age-related macular degeneration (AMD), one of the leading causes of blindness, we have many years of experience. We developed the use of time-lapse imaging for AMD, which helps to understand the mechanisms of progression of the disease. For this, we collect images of patients with AMD for periods up to 10 years, and time lapse movies are constructed so as to track the progression of the disease over time. We are working on algorithms to allow automated border progression detection to serve as a clinical diagnostic aid.
Color fundus (top left) and montages of adaptive optics flood images of geographic atrophy in AMD, with zooms showing atrophy borders and arrows indicating characteristic features of mobile pigment clumps.
Paques M, Meimon S, Mrejen S, Rossant F, Rosenbaum D, Sennlaub F, Grieve K.
Prog Ret Eye Res, online 17 July 2018 (2018).